The Sixers made 8/137 at Adelaide Oval in reply to 135 to make it five in a row for the men in magenta.
Coming to the crease, needing 11 to win from as many balls, the Bendemeer Bullet showed just as much class as he does with the ball to grab what looked like an unlikely win halfway through the run chase.
When Afghan leg-spinner Rashid Khan (4-22) claimed a hat-trick in the middle of the chase, it looked as though the win had slipped away. However, England allrounder Tom Curran steadied the ship, with 21 from 20 balls, to give the Sixers a chance.
Curran also claimed personal best figures in the BBL finishing with 4-22 from 3.4 overs including two in the final over.
It was again a complete bowling performance by the Sixers attack dismissing the Strikers in 19.4 overs.
Left-arm quick Ben Dwarshuis claimed 2-20 from his four and leg-spinner Lloyd Pope also returned 2-33.
Hazlewood was again at his economical best with 1-19 from four overs after returning 1-18 from his four in the win over the Strikers at C.ex Coffs International Stadium on Sunday night.