Healy's unbeaten knock led the Sixers to a season-best 3-161 and the Scorchers never quite got going in reply, with Nicole Bolton capturing 3-11 against her old side as the hosts were restricted to 9-117.
After a string of single-digit scores, Healy made a statement in her second half-century of the season, as her 57-ball knock helped the Sixers post 3-161.
The Sixers stuck with the Healy-Perry opening combination, a change they made for Saturday's game given the pair's strong record on Western Australian wickets.
It proved a canny call as the pair put on 101 for the first wicket, Healy racing to fifty from 31 balls; their stand only broken when Taneale Peschel bowled Perry for 31 in the 13th over.
Former Sixers bowler Lisa Griffith came in for some punishment from her former teammate, Healy plundering a total of 12 fours and two sixes in her whirlwind innings.
Perry played a handy support role scoring a 39-ball 31, but Ashleigh Gardner's below-par form with the bat continued as she scratched her way to a 16-ball eight. The damaging allrounder has reached double figures just once in six innings this tournament.
Perry then struck the crucial blow with the ball, removing in-form Scorchers captain Sophie Devine for six, and while Beth Mooney (30) and Chloe Piparo (29) dug in, neither could replicate Healy's free-scoring innings.
Bolton dismissed Piparo and Chamari Athapaththu in the space of four balls; when Mooney followed the next over, the Scorchers were reeling at 4-71 and never recovered.
Lauren Cheatle's excellent weekend continued as the left-arm quick took 2-13 from her four overs, while left-arm spinner Radha Yadav (2-22) also impressed.
Sydney Sixers WBBL|07 Schedule (All AEDT Start Times)
Wed 3 Nov | v Hobart Hurricanes | 1:25pm | WACA Ground | Foxtel/Kayo/cricket.com.au
Tues 9 Nov | v Brisbane Heat | 2:35pm | Karen Rolton Oval | Foxtel/Kayo/cricket.com.au
Wed 10 Nov | v Adelaide Strikers | 4:50pm | Karen Rolton Oval | Foxtel/Kayo/cricket.com.au
Sat 13 Nov | v Brisbane Heat | 7:05pm | Great Barrier Reef Arena | Seven/Foxtel/Kayo
Sun 14 Nov | v Sydney Thunder | 1:40pm | Great Barrier Reef Arena | Seven/Foxtel/Kayo
Sat 20 Nov | v Adelaide Strikers | 1:40pm | Adelaide Oval | Seven/Foxtel/Kayo
Sun 21 Nov | v Perth Scorchers | 10:15am | Adelaide Oval | Seven/Foxtel/Kayo