In reply to the home side’s 6/153, the Sixers made 4/154 from 19.5 overs.
Jordan Silk steered the Sixers to victory with 36 not out from 26 balls, including two sixes, and in the process passed 1,000 BBL runs, the fourth Sixer to do so.
Silk now has 1,033 runs from 58 matches. He was well supported towards the end of the chase by England International batsman James Vince (41 from 26).
Sixers opening pair Daniel Hughes (40 from 31) and wicketkeeper-batter Josh Philippe (33 from 30) made a steady start to the chase combining for 70 from 55 deliveries. However, three quick wickets for 10 brought the Renegades back into the contest.
Sixers leg-spinner Lloyd Pope was again impressive taking 2-22 from his four overs following 3-23 from four in the win over Sydney Thunder at the SCG on Saturday night.
Seamer Jackson Bird was next best against the Renegades with 2-24 from his four overs. Keeper-batter Sam Harper top-scored for the hosts with 45 from 24 balls, one of three batsmen to pass 30.
The Sixers now travel to Coffs Harbour for their next home match against the Adelaide Strikers on Sunday night.