The visitors won the toss and elected to bat first, in what was a rematch of the tournament's opening fixture that saw the Hurricanes prevail in a Super Over thriller.
Led by Max Wright (79 off 59 balls), Hobart got off to a rapid start, flying along to 1/95 midway through their innings.
However, the Sixers fought back and regained some control courtesy of economic bowling from Tom Felton (1/24 off 4 overs) and Nick Stapleton (1/26 off 4 overs).
Param Uppal also contributed a pair of handy overs towards the death, finishing with figures of 1/14 as the Hurricanes posted a very competitive total of 6/173.
Sixers Academy captain Jack Edwards ensured the home team's run chase started in the best possible fashion, clearing the boundary rope on a number of occasions in an explosive innings of 33 off just 14 balls.
Luke Bartier (36 off 33 balls) looked to play the role of anchor, but wickets continued to fall steadily around him, with the Sixers finishing with 8/147 from their 20 overs.