After being set 125 for victory, the Sixers cruised to the total in the 15th over after Daniel Hughes (51 not out) and Moises Henriques (61 not out) took the game by the scruff of the neck on Tuesday night.
The Strikers were never really in the match after being restricted to 8-124 on the back of a stellar spell by Ben Dwarshuis (3-7).
The Strikers' innings was highlighted by Alex Carey falling victim to his fourth run out of this BBL to continue his lacklustre summer.
The home side was in a spot of bother at 2-24 - after Josh Philippe (4) was caught lbw, four balls after being struck in the ribs by Billy Stanlake who then had James Vince (9) caught at cover point.
Hughes and Henriques showed cool heads to guide the side to their third win on the trot and keep them in second spot, three points ahead of the fifth-placed Sydney Thunder.
Earlier, the Strikers were rocked at 1-4 in the first over after Australian limited overs keeper Carey was run out for just four.
Carey was out to an embarrassing mix-up with opening partner Jake Weatherald - the second time he has been run out against the Sixers this BBL season.
Dwarshuis recorded career-best T20 figures, including the key wicket of Jake Lehmann (46).
Lehmann was the only Striker to make a meaningful contribution with five Adelaide batsmen failing to reach double figures.
It leaves the Strikers four points behind the fourth-placed Melbourne Stars with three games remaining, making another title shot unlikely this season.
The Sixers can secure a finals spot with a win over the Thunder at the SCG on Saturday.