After containing the Renegades to 8-120 from their 20 overs, the Sixers took their run chase right down to the wire, only for a composed Ellyse Perry to seal the win with a ball to spare.
Perry, dropped on five when Danni Wyatt put down a sitter, anchored her team’s chase with an unbeaten 45.
The dismissals of the in-form Alyssa Healy (11) and Ashleigh Gardner (0) ignited the Renegades’ hopes, but Dane van Niekerk’s 27-ball 30 kept the chase on track.
Late strikes from Maitlan Brown (2-18) and Molly Strano (1-24) took the game into the last over, but Perry – who found the boundary just three times in her 50-ball innings – timed the chase to perfection.
Earlier, the Renegades lost openers Sophie Molineux (4) and Wyatt (2) cheaply and while Tammy Beaumont and Courtney Webb came together to steady proceedings, they struggled to keep the scoreboard ticking over.
At 2-32 after 10 overs, Webb and Beaumont finally started to up the run rate and took 16 runs from the 13th over, only for the Sixers to hit back emphatically with three wickets in the space of three balls to start the 14th.
First Webb was run out, before Beaumont was bowled and Georgia Wareham trapped lbw from consecutive Marizanne Kapp deliveries.
Renegades captain Jess Duffin produced a critical 34no from 22 came as the wickets continued to fall at the other end, clearing the ropes twice to help her team to 8-120.
South African imports Kapp (2-21) and van Niekerk (2-15) led the wicket-taking as the Sixers picked up their third win from four matches to date.