The fixture ended in a draw, with Sixers players making an impact and providing tough competition for the hosts.
Daniel Hughes (60) and Moises Henriques (47) both made valuable contributions to NSW's first innings total of 246.
Sean Abbott (2/64) and Stephen O'Keefe (1/51) got through plenty of overs as South Australia built a 27-run first innings lead.
In response Sixers wicketkeeper Peter Nevill proved his leadership abilities as NSW Captain, guiding the squad in almost achieving an improbable victory.
Nevill (72 not out) formed a key partnership with the recently signed impressive young Sixers player Jack Edwards (30) in the Blues second innings, before declaring at 8-279 and establishing target of 253 for SA in the final session.
Sixers seam bowler, Abbott was a stand out on the final day, securing 3-29 in a blistering spell which saw him find the edge of key players Callum Ferguson and Harry Nielson’s bats and dismiss Tom Cooper with an LBW.
In the end however, the Blues came up just four wickets short of an outright victory.The NSW squad are set to come up against Victoria in the second round of the Sheffield Shield on 25 October at the MCG.